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About Trioday®

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Description

Trioday® is manufactured by Cipla. Trioday® comprises three active ingredients, including Lamivudine and Tenofovir, which are nucleotide reverse transcriptase inhibitors (NRTIs), and Efavirenz – non-nucleoside reverse transcriptase inhibitor (NNRTI).

Indications:

- human immunodeficiency virus type 1 (HIV-1) infection in adults 18 years of age.

MOA (mechanism of action):

Tenofovir (TDF) and Lamivudine (3TC) are known as NRTIs and they work by interfering with the normal working of an enzyme reverse transcriptase that is crucial for the HIV to reproduce itself. Efavirenz (EFV) binds directly to the HIV-1 RT, an RNA-dependent DNA polymerase, suppressing its function in viral DNA replication. Therefore, Trioday® reduces the viral load in blood, increases the count of CD4 (T) cells in blood which aids in warding off other infections. Tenofovir, Lamivudine, Efavirenz are not active against HIV-2.

Dosage

The usual dose of Trioday® is one tablet once a day, at the same time.

Take Trioday® on an empty stomach (2 hours after food) at bedtime. Bedtime dosing helps reduce the impact of some of the side effects, especially during the first few weeks.

Do not run out of Trioday®. Refill the prescription or talk to your doctor before Trioday® is gone.

Precautions:

HIV can be transmitted through sexual contact with infected partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both infected and non-infected individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Some people who take Trioday® may experience:

- Lactic acidosis (a buildup of lactic acid in the blood). The symptoms are unexpected tiredness or weakness, nausea or vomiting, constant abdominal pain, pancreatitis. If any of these symptoms occur, seek emergency medical attention immediately.

- Severe acute exacerbations of hepatitis B may develop in patients who are co-infected with HBV and HIV-1 and have discontinued tenofovir disoproxil fumarate or lamivudine, both of which are components of Trioday®. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue anti-hepatitis B therapy including Trioday® and are co-infected with HIV-1 and HBV. If appropriate, initiation of anti-hepatitis B therapy may be warranted.

- Immune Reconstitution Syndrome – a condition when immune system may get stronger and starts fighting infections that have been hidden in the body for a long time.

Missing a dose

If you notice a missing within 12 hours of the time you usually take Trioday®, you must take the tablet as soon as possible. Then take the next dose as usual. If you notice 12 hours or more after the time you usually take Trioday®, then do not take the missed dose. Wait and take the next dose at your usual time. Do not take a double dose of Trioday® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Trioday® tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Trioday® in the original container. Do not use Trioday® if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common and uncommon side effects associated with Trioday® are:

  • rash
  • dizziness
  • nausea
  • headache
  • fatigue
  • insomnia
  • vomiting

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Trioday® is contraindicated in patients who are allergic to Lamivudine, Tenofovir, Efavirenz or any of the other ingredients of Trioday®.

Do not use Trioday® in patients under 18 years of age and in patients over 65 years of age.

Do not let your Trioday® run out. Refill your tablets if therapy is continued.

Do not stop taking Trioday® suddenly and without first talking to the doctor.

Trioday® is not indicated for the treatment of chronic hepatitis B (HBV). Thus, Trioday® isn't for use in patients co-infected with HBV and the human immunodeficiency virus type 1 (HIV-1).

Do not take Trioday® if you have liver problems, including HBV infection, kidney problems, bone problems, a history of mental illness (depression, alcohol abuse), a history of convulsions (fits or seizures), diabetes, high cholesterol.

Do not combine Trioday® with other medicines that contain Tenofovir (Complera®, Stribildtm, Truvada), adefovir (Hepsera®), didanosine (Videx, Videx EC), atazanavir (Reyataz), lopinavir with ritonavir (Kaletra), darunavir (Prezista), ledipasvir with sofosbuvir (Harvoni®), sofosbuvir with velpatasvir (Epclusa®), astemizole or terfenadine, bepridil, cisapride, ergot alkaloids, midazolam or triazolam, pimozide, voriconazole, acyclovir, adefovir dipivoxil, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), anticonvulsants (carbamazepine, phenytoin, phenobarbital), immunosuppressants, anticoagulants, antidepressants (Sertraline), antifungals (itraconazole or posaconazole), methadone (to treat opiate addiction), high-dose or multiple NSAIDs, products containing St John’s wort, calcium or iron supplements, multivitamins.

Women should not become pregnant and should use two effective birth control methods while taking Trioday® and for 12 weeks after stopping it. A barrier form of contraception like condom, contraceptive sponge, diaphragm, cervical cap should always be used along with another method of contraception.

Hormonal contraceptives like pills, injections, vaginal rings, or implants may not work during treatment with Trioday®.

Do not take Trioday® if you are pregnant or plan to have baby, are breastfeeding or plan to breastfeed.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Alcoholism, hepatic disease, hepatotoxicity or lactic acidosis, obesity, organ transplantation are contraindications for using Trioday®.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Q: What is Trioday® used for?

A: Trioday® is an anti-retroviral medication which combines three active ingredients and is indicated to treat HIV-1 in adults who reached 18 years. Trioday® tablets lower the viral load and control HIV-1. Trioday® cannot cure HIV-1 and AIDS. Not for use in patients co-infected with HBV and HIV-1.

Q: Can I have sex when taking Trioday®?

A: You should know neither Trioday® nor any other anti-retroviral medication can cure HIV. It is therefore important that you have safe sex and take other precautions to avoid passing HIV on to other people. Do not have any kind of sex without using a latex or polyurethane condom.

Q: Is Trioday® safe during pregnancy?

A: Do not take Trioday® if you are pregnant or plan to have baby, are breastfeeding or plan to breastfeed.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide shipping

Worldwide shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
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