Description
Ciplox® is manufactured by Cipla.
Ciplox® tablets contain a key ingredient called Ciprofloxacin, that is a synthetic, second generation antibiotic from Fluoroquinolones family.
Indications:
- infections of upper/lower respiratory tract (RTIs) (acute and chronic bronchitis, obstructive airways disease (COPD), empyema, lung abscess, bronchiectasis, lobar and bronchopneumonia, acute exacerbation of cystic fibrosis, otitis media, sinusitis and mastoiditis);
- infections of urinary tract (acute and chronic pyelonephritis, cystitis, urethritis, prostatitis, epididymitis and chronic complicated or recurrent UTI caused by multi-drug resistant organisms and/or Pseudomonas aeruginosa);
- infections of the skin and soft tissue (infected ulcers, wound infections, abscesses, cellulitis, erysipelas, infected burns);
- surgical infections (peritonitis, intra-abdominal abscess, cholangitis, cholecystitis, empyema of gall bladder);
- bone and joint infections (acute and chronic osteomyelitis, septic arthritis);
- pelvic infections (Salpingitis, endometritis, pelvic inflammatory disease);
- sexually transmitted diseases (STDs) (Gonorrhoea);
- gastrointestinal infections (enteric fever, infective diarrhea);
- severe systemic infections (Septicaemia, bacteremia, infections in immunocompromised patients).
Note, that taking Ciplox® may induce tendinitis/tendon rupture. Therefore, certain individuals are at a higher risk, including those who are over 60 years of age, are taking corticosteroid drugs, have kidney, heart or lung transplants, suffer from musculoskeletal disorders.
MOA (mechanism of action):
Ciprofloxacin is an antimicrobial agent, that inhibits the bacterial DNA gyrase enzyme, required for bacterial DNA replication, transcription, repair and recombination.
Ciprofloxacin is effective against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, Staphylococcus epidermidis and Streptococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogenes, Campylobacter jejuni, Shigella flexneri and Shigella sonnei.
Dosage
Ciplox® pills should be swallowed whole and taken with a full glass of water.
Do not stop taking Ciplox® suddenly.
The usual dose for most infections is 500 mg twice daily during 7-14 days.
For infections of the respiratory tract: 500 mg twice daily to 750 mg twice daily (7-14 days).
For malignant external otitis: 750 mg twice daily (28 days up to 3 months).
For infectious diarrhea: 500 mg twice daily (3-7 days).
For urinary tract infections:
acute uncomplicated cystitis – 250 mg twice daily;
mild to moderate – 250 mg twice daily;
severe or complicated – 500 mg twice daily.
Treatment is required for 3-10 days.
For skin and soft tissue infections:
mild to moderate – 500 mg twice daily;
severe or complicated – 750 mg twice daily (7-14 days).
For bone and joint infections:
mild to moderate 500 mg twice daily;
severe or complicated – 750 mg twice daily.
Treatment may be required for 4-6 weeks or longer.
For STDs:
Gonorrhoea: 250 mg as single dose.
For pelvic infections:
Epididymo-orchitis and pelvic inflammatory disease: 500 mg twice daily to 750 mg twice daily (14 days).
Elderly patients should receive a lower dose.
Patients with reduced renal function, the half-life of Ciprofloxacin is prolonged and the dosage needs to be adjusted.
Missing a dose
If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Ciplox® to compensate the missed dose.
Overdose
If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.
Storage
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.