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Synthivan®

Synthivan® is a fixed-dose combination drug used for the treatment of HIV-1 infection in adult patients over 18 years of age. It comprises two active ingredients allowing the medication to be more effective. Synthivan® treats, controls but doesn't cure HIV or AIDS.

Other names for this medication:
Ritovaz®, Atazor R®, Virataz R®, Anzavir R®, Ataclip®

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USD 250.95 per bottle   -20% USD 313.69 USD 250.95 per 1 bottle   Order now
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Description

Synthivan® is manufactured by Cipla. The raw materials are Ritonavir (RTV) – a peptidomimetic inhibitor of the HIV-1 protease, and Atazanavir (ATV) – an azapeptide HIV-1 protease inhibitor (PI).

Indications:

- treatment of HIV type 1 infection in adults.

Synthivan® is not recommended for treatment-experienced adult or pediatric patients with prior virologic failure.

MOA (mechanism of action):

The principal action of Atazanavir and Ritonavir is to inhibit the virus-specific processing of viral Gag-Pol proteins in HIV-1 infected cells, thus averting formation of mature virions and infection of other cells. Ritonavir 100 mg is usually used as a pharmacokinetic booster of plasma levels of concomitantly administered protease inhibitors. Boosted protease inhibitors are currently considered the standard of care in HIV therapy.

Dosage

Concomitant therapy in treatment-naive patients

For treatment-naive patients: 1 tablet with food per day.

One Synthivan® tablet once daily with food if combined with any of the following:

Tenofovir;

H2-receptor antagonist (Famotidine 40 mg twice daily). Synthivan® tablets should be administered concomitantly with, and/or at least 10 hours after, the dose of the H2-receptor antagonist;

Proton-pump inhibitors (Omeprazole 20 mg and must be taken approximately 12 hours prior to the Synthivan® dose);

Concomitant therapy in treatment-experienced patients

For treatment-experienced patients: 1 tablet with food per day.

H2-receptor antagonist dose should not exceed a dose comparable to Famotidine 20 mg twice daily. Synthivan® tablets should be administered concomitantly with, and/or at least 10 hours after, the dose of the H2-receptor antagonist.

One Synthivan® tablet once daily with food if taken with an H2-receptor antagonist.

Do not administer Synthivan® tablets if both Tenofovir and an H2-receptor antagonist have to be taken together.

Proton-pump inhibitors are not to be used in treatment-experienced patients receiving Synthivan®.

Do not combine Synthivan® with Efavirenz in treatment-experienced patients due to decreased Atazanavir exposure.

Precautions:

HIV can be transmitted through sexual contact with HIV positive partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both HIV-positive and HIV-negative individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Synthivan® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Synthivan® tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Synthivan® in the original container. Do not use Synthivan® if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common and uncommon side effects associated with Synthivan® are:

  • rash
  • headache
  • dizziness
  • vomiting
  • crystals in urine
  • nausea
  • abdominal pain
  • dyspepsia
  • paresthesia
  • throat pain
  • increased liver enzymes
  • diarrhoea
  • blood in urine
  • peripheral neuropathy (tingling and numbness of feet and hand)
  • cough
  • altered taste
  • increased cholesterol level
  • increased triglyceride level
  • protein in urine

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Synthivan® is contraindicated in patients who are allergic to Atazanavir, Ritonavir or any of the other ingredients of Synthivan®.

Do not use Synthivan® in patients younger than 18 years.

Synthivan® is contraindicated in patients with severe hepatic insufficiency, including chronic hepatitis B or C.

Synthivan® with ritonavir is contraindicated in patients with moderate hepatic insufficiency.

Do not combine Synthivan® with simvastatin or lovastatin, rifampicin, PDE5 inhibitors, substrates of the CYP3A4 isoform of cytochrome P450 (quetiapine, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine), sedative hypnotics, antiarrhythmics, ergot alkaloids (ergotamine, dihydroergotamine, ergonovine, methylergonovine), products containing St. John’s wort, atorvastatin, other anti-retrovirals (NNRTI or PI) like nevirapine or indinavir, salmeterol, hormonal contraceptives, glucocorticoids (fluticasone), voriconazole, antineoplastics (irinotecan), benzodiazepines (triazolam, oral midazolam), neuroleptics (pimozide).

Do not use Synthivan® with efavirenz or proton-pump inhibitors in treatment-experienced patients.

Synthivan® should be used with particular caution in association with medicinal products which can increase the QT interval and/or in patients with pre-existing risk factors (bradycardia, long congenital QT, electrolyte imbalances.

Synthivan® should be used with particular caution in hemophiliac patients due to the possibility of increased bleeding.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Do not take Synthivan® if you are pregnant or plan to have a baby without prior consulting with your healthcare provider.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Q: What is Synthivan® used for?

A: Synthivan® is a fixed-dose combination drug used for the treatment of HIV-1 infection in adult patients over 18 years of age. It comprises two active ingredients allowing the medication to be more effective. Synthivan® treats, controls but doesn't cure HIV or AIDS.

Q: Can I have sex when taking Synthivan®?

A: You should know neither Synthivan® nor any other anti-retroviral medication can cure HIV. It is therefore important that you have safe sex and take other precautions to avoid passing HIV on to other people. Do not have any kind of sex without using a latex or polyurethane condom.

Q: Can I breastfeed if I take Synthivan®?

A: Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide shipping

Worldwide shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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