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About Prozac

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Description

Prozac comprises an active ingredient Fluoxetine, an antidepressant belonging to a class selective serotonin reuptake inhibitors (SSRIs) (second-generation antidepressants).

Indications:

- major depressive disorder (MDD) or depression (feeling sad, inability to sleep properly or to enjoy life as one used to);

- obsessive-compulsive disorder (OCD) (obsessive repetitive actions like hand-washing, counting, checking);

- bulimia nervosa (an eating disorder characterized by binge-eating and purging);

- panic disorder, with or without agoraphobia (excessive and persistent fear of public places or open areas);

- depressive episodes associated with Bipolar I Disorder (only in combination with another medication like Olanzapine);

- off-label treatment of premature ejaculation (PE), (or too early ejaculation within 1 minute after penetration).

MOA (mechanism of action):

Fluoxetine slows the reabsorption of serotonin in the brain. Serotonin is a chemical neurotransmitter, which sends electrical messages between nerve cells (neurons). Usually, serotonin is quickly reabsorbed, but Fluoxetine lets the serotonin remain in the synaptic gap between neurons for a longer period of time. This allows the chemical to send additional messages to the receiving neuron, which results in improvement in mood.

Dosage

Swallow a capsule whole with a drink of water.

Prozac should only be used in children and adolescents aged between 8-18 years for the treatment of moderate to severe depression (alongside psychological therapy).

For depression and OCD: 20 mg once daily dose. The daily dose may be increased later if no clinical improvement is observed.

For bulimia: 20 mg three times daily.

For panic disorder: 10 mg/day. After one week increase the dose to 20 mg/day. The dose may be increased after several weeks if no clinical improvement is observed.

Take Prozac at the same time each day.

Treatment in children should be held under the doctor's supervision.

Precautions:

Do not stop taking Prozac after a week or two, feeling it doesn't work.

It can take up to 2 weeks after starting this treatment before positive effect appear, and 4-6 weeks before a patient feels the full benefit.

Be careful while taking Prozac tablets if you have diabetes, as it may alter your blood glucose levels and your insulin/medication may need adjusting.

When stopping treatment with Prozac, it is best to decrease the dose gradually over a period of several weeks or months to minimize the withdrawal reactions.

Avoid consuming alcohol while taking Prozac.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Prozac to compensate the missed dose.

Overdose

If you take an overdose of Prozac, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Prozac are:

  • allergic reactions (wheeziness, difficulty in breathing or dizziness, swelling of the eyelids, face, lips or throat, rash, convulsions)
  • insomnia
  • dizziness
  • sleepiness
  • headache
  • diarrhea
  • feeling sick
  • dry mouth
  • fatigue
  • sore throat
  • depression
  • anxiety
  • agitation
  • nervousness
  • decreased sexual interest
  • teeth grinding
  • numbness and tingling
  • shaking
  • muscle tense
  • abnormal taste
  • lack of attention
  • visual disturbance
  • ringing in ears

Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Prozac if you are allergic to Fluoxetine or any of the other ingredients in the tablets.

Do not take Prozac if you are taking or have taken monoamine oxidase inhibitor drug (MAOI) (selegiline, moclobemide), or MAOI-like drug (linezolid) for depression.

Do not take Prozac you are taking pimozide (drug for the treatment of mental disorders like schizophrenia or psychosis).

Do not take Prozac if you suffer from epilepsy, have a history of seizures. or are receiving ECT (electroconvulsive therapy).

Do not take Prozac if you suffer or have suffered from manic depressive illness (bipolar disorder) or schizophrenia.

Do not take Prozac if you have suffered from a bleeding disorder or have been taking anticoagulants (e.g. acetylsalicylic acid, warfarin).

Do not take Prozac if you have or have previously had thoughts of harming or killing yourself.

Do not take Prozac if you have serotonin syndrome, low sodium levels in your blood, liver disease, have or have a history of angle-closure glaucoma.

Prozac is only for use in adults (over 18 years of age). It can only be used to treat children and adolescents aged 8-18 years old with obsessive compulsive disorder (OCD).

Prozac is not recommended for use if you are pregnant, likely to become pregnant or are breastfeeding until your doctor decides if this medication is right for you.

Do not drive or operate machinery while treatment with Prozac.

Consult your doctor prior taking Prozac if you are taking any of the following medications: amino acid tryptophan (for depression), diazepam (a sedative), lithium (for mania and depression), anesthetics (fentanyl), tricyclic antidepressants (imipramine), medications for schizophrenia and other mental disorders (perphenazine, levomepromazine, olanzapine), medications to treat diabetes (tolbutamide), cimetidine (for ulcers), non-steroidal anti-inflammatory drugs (NSAIDs), diuretics (water pills), medications to treat epilepsy (phenytoin, phenobarbital, carbamazepine), tramadol (a painkiller), sumatriptan (for migraine), fenfluramine (appetite suppressant), herbal remedy St. John’s Wort, drugs used to regulate the rate and rhythm of the heart (flecainide, propafenone, verapamil, diltiazem), drugs used to treat fungal infections (ketoconazole, itraconazole, posaconazole, voriconazole, fluconazole), drugs used to prevent nausea and vomiting after an operation or chemotherapy (aprepitant).

Q: What is Prozac?

A: Prozac is a psychiatric drug used for the treatment of mood disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic attacks, eating disorder etc. Taking Prozac capsules, unpleasant symptoms like fear, anxiety, harmful thoughts, compulsive actions are fade away. Prozac is not for use in patients under 8 years of age.

Q: Does Prozac cause dependence?

A: Prozac is not addictive. However, sudden stopping or decrease in dose of Prozac may cause withdrawal reactions like dizziness, numbness, sleep disturbances, agitation or anxiety, headaches, nausea, vomiting and shaking. Consult the doctor regarding the use of Prozac and discontinuation.

Q: Is Prozac a stimulant?

A: No, it isn't. Prozac is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It does not stimulate the brain but improves depression by increasing the levels of a chemical called serotonin in the brain.

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