About Cerazette®

Description

Cerazette® is manufactured by Organon.

Cerazette® contains an active compound Desogestrel, which is similar to the natural female sex hormone progestogen.

Desogestrel is a third generation progestin which has a favorable effect on a lipid profile and is twice as potent as contraception pills with Levonorgestrel. Desogestrel provides high efficacy with fewer side effects.

MOA (mechanism of action):

Desogestrel works primarily by preventing the release of an egg from the ovary (stops ovulation). It also increases the thickness of the natural mucus at the neck of the womb, making it more difficult for sperm to reach the womb. This minimizes the successful fertilization of any egg that is released. Desogestrel also changes the quality of the womb lining (endometrium). This prevents the attaching of a fertilized egg onto the womb, thereby preventing pregnancy.

Dosage

Cerazette® tablets must be taken on a regular basis, at the same time every day.

Cerazette® tablets are taken without a break, including when you are having a period.

It is recommended to start taking Cerazette® on the first day of your period..

If necessary, you can also start taking it up to day five of your cycle without needing to use an additional contraceptive when you start.

In case you have a short menstrual cycle (with your period coming every 23 days or less), starting as late as the fifth day of your cycle may not provide you with immediate contraceptive protection..

If you start taking Cerazette® at any other time in your cycle, you will need to use additional contraception, e.g. condoms for the first two days of taking Cerazette®.

If you start taking Cerazette® on day 21 after delivery, you are protected against pregnancy immediately and do not need to use extra contraception.

If you start taking it later than 21 days after delivery, you should use extra contraception for the first two days.

If you start Cerazette® immediately after a miscarriage or abortion at under 24 weeks, you will be protected against pregnancy immediately.

If you start taking it more than seven days after the miscarriage or abortion, you should use extra contraception for the first two days of pill taking.

If you are less than 12 hours late in taking your next dose or if you vomit, or use medical charcoal within 3 - 4 hours or have severe diarrhea, take the missed tablet as soon as you remember and take the next one at the usual time.

Missing a dose

If you are more than twelve hours late taking your Cerazette® daily dose, you will not be protected against pregnancy. You should use a back-up contraception, e.g. condoms, for the next two days, while continuing your regular dosing schedule.

Overdose

If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated Cerazette® are:

• nausea
• ovarian cysts
• skin lumps
• acne
• breast pain
• abnormal milky discharge from breast
• breast secretion
• decreased libido
• difficulty in wearing contact lenses
• painful periods
• absence of periods
• hair loss
• headache
• irregular menstrual cycle
• mood swings
• urticaria
• vaginal infection
• vomiting
• fatigue
• weight gain

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cerazette® if you are allergic to its components.

Do not take Cerazette® if you are using another oral contraception.

Do not take Cerazette® if you have deep venous thrombosis (blood clot) or thromboembolic disorders.

Do not take Cerazette® if you have a known or suspected hormone-dependent tumor such as breast or endometrial carcinoma.

Do not take Cerazette® if you have jaundice, severe liver disease or a history of liver disease.

Do not take Cerazette® if you have high blood pressure or diabetes.

Do not take Cerazette® if you have any unexplained vaginal bleeding.

Do not take Cerazette® if you are pregnant or plan to have a baby.

Do not take Cerazette® if you are taking medications that interact with Cerazette®, including anticonvulsants (e.g., phenytoin, carbamazepine, topiramate), barbiturates (e.g. Phenobarbital), anti-infectives (e.g., rifampicin, rifabutin, nelfinavir, griseofulvin, cyclosporine), St John's Wort, medical charcoal.

Do not take Cerazette® if you have or have had chloasma (patches of yellow/brown pigmentation).

Cerazette® is not a method of emergency contraception.

Cerazette® doesn't protect you and your partner from sexually transmitted diseases (HIV and the others).

Keep Cerazette® away from children and don't give it to other people for using.

Q: How does Cerazette® work?

A: MOA (mechanism of action): Desogestrel works primarily by preventing the release of an egg from the ovary (stops ovulation). It also increases the thickness of the natural mucus at the neck of the womb, making it more difficult for sperm to reach the womb. This minimizes the successful fertilization of any egg that is released. Desogestrel also changes the quality of the womb lining (endometrium). This prevents the attaching of a fertilized egg onto the womb, thereby preventing pregnancy.

Q: Is Cerazette® safe?

A: Cerazette® is safe in most women, if taken as recommended. Common side effects of desogestrel include weight gain, irregular or no periods, hair loss. Blood clot is a rare side effect of Cerazette®.

Q: Is Cerazette® a combined contraceptive?

A: Cerazette® is a new, potent progestogen with very low androgenic properties. It is not a combined contraceptive medication; it is a progestogen-only-pill.

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