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About Eukroma®-Plus Cream

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Eukroma®-Plus Cream is manufactured by Yash Pharma. This is an anti-pigmentation cream used to lighten the darkened areas of the skin, including freckles, chloasma (also known as melasma), age spots, liver spots and even acne scars. The active substances comprised in Eukroma®-Plus Cream are Hydroquinone, Tretinoin, and Mometasone Furoate. Hydroquinone is a benzene derivative of phenol type and a topical lightening agent. Tretinoin is a retinoid and vitamin A (retinol) derivative with keratolytic and comedolytic effects. Mometasone Furoate is a corticosteroid of glucocorticoid class with strong anti-inflammatory properties.

Hyperpigmentation is a skin disorder associated with melanin (naturally produced pigment) overproduction. Its symptoms are light to medium brown spots on the skin. Hyperpigmentation is thought to be caused by genetic predisposition, sun exposure, pregnancy, hormone treatments, skin trauma, use of perfumes and deodorants, or hypothyroidism (low thyroid hormone).

MOA (mechanism of action):

Hydroquinone inhibits tyrosinase, the enzyme responsible for melanin production, therefore breaks down the melanin pigment granules in the skin pigment cells (melanocytes) and allows brown patches come back to a normal complexion.

Tretinoin binds to specific retinoic acid receptors and regulates cell differentiation and growth. It promotes new epithelial cells production while exfoliating the old skin cells. By these actions, Tretinoin speeds up the cells turnover rate and makes the lightening of the skin more rapid.

Mometasone Furoate acts as an anti-inflammatory agent blocking the release of inflammatory mediators, such as prostaglandins and leukotrienes. It also decreases the risk of contact dermatitis development that may appear due to the Hydroquinone and Tretinoin application.


Eukroma®-Plus Cream is for external use only. Do not apply to your eyes, mouth, inside of the nose, private parts, and any other mucosal surface.

Eukroma®-Plus Cream should be applied 1-2 times daily, preferably in the morning and at bedtime.

Eukroma®-Plus Cream is usually applied from several weeks to 2-3 months depending on skin condition and tolerance. Use Eukroma®-Plus Cream as long as recommended by your doctor.

How to use Eukroma®-Plus Cream:

1. Wash your hands and make sure the affected areas are clean and dry.

2. Take a small amount of the cream and gently massage it over the affected area avoiding mucosal surfaces.

3. Wash your hands after the cream application.


Do not use Eukroma®-Plus Cream for longer than 6 months.

You should use sunscreen product (SPF 15 at least) during the Eukroma®-Plus Cream treatment course.

If you need to treat a large area of the skin with Eukroma®-Plus Cream, divide the application into a few sessions. Do not apply this cream to large areas at once.

If you have sensitive skin, it is recommended to test the sensitivity to Eukroma®-Plus Cream. Apply a small amount of the cream to the inner side of your arm and wait for 24 hours. If no hypersensitivity reactions occur (such as severe itching, burning, swelling, vesicle formation, and inflammation), you can start the regular Eukroma®-Plus Cream treatment course.

Do not apply Eukroma®-Plus Cream to the irritated, itchy, cracked or burnt skin (sunburns and windburns included).

Do not cover the Eukroma®-Plus Cream application site with occlusive bandages or other covering.

Do not use Eukroma®-Plus Cream in combination with harsh skin products, medicated soaps and shampoos, products with drying effect on the skin, peeling agents, products containing alcohol, spices or lime.

Do not get permanent wave solutions and waxing products on skin being treated with Eukroma®-Plus Cream.

Do not apply skin moisturizers or makeup to the skin being treated with Eukroma®-Plus Cream 1 hour before and after the gel application.

Patients should use sunscreens (min. SPF 15) and protective clothing while using Eukroma®-Plus Cream.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.


Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

Side effects

The most common side effects associated with the use of Eukroma®-Plus Cream are:

  • dry skin
  • itchiness
  • irritated skin
  • burning or stinging sensation
  • scaling
  • skin rash
  • contact dermatitis

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.


Do not apply Eukroma®-Plus Cream if you are allergic to Hydroquinone, Tretinoin or Mometasone Furoate.

Do not apply Eukroma®-Plus Cream if you have a history of severe allergic reactions associated with the use of retinoids, corticosteroids or skin bleaching products.

Do not apply Eukroma®-Plus Cream if you are allergic to any of the other ingredients comprised in Eukroma®-Plus Cream.

Do not apply Eukroma®-Plus Cream if you have eczema, rosacea, hepatic disease or perioral dermatitis.

Do not use Eukroma®-Plus Cream if you or any of your family members have ever had an epidermal tumor.

Do not use Eukroma®-Plus Cream if you are taking any pain medications (aspirin, ibuprofen, meloxicam, tramadol), asthma drugs (albuterol), antibiotics (clindamycin, doxycycline, minocycline), peroxides, omega-3 polyunsaturated fatty acids (fish oil), muscle relaxers (cyclobenzaprine), corticosteroids (fluticasone, prednisone), epilepsy drugs (gabapentin, clonazepam), hormones (melatonin), stomach drugs (omeprazole), antidepressants (trazodone, alprazolam) or antihistamines (cetirizine).

Do not use Eukroma®-Plus Cream if you have skin cancer, skin photosensitivity disorder, sunburn or sunlight (UV) exposure.

Do not apply Eukroma®-Plus Cream if you have sunburn, windburn or skin irritation with redness, peeling or itching.

Eukroma®-Plus Cream is strictly prohibited for women who are pregnant, planning to have a baby or breastfeeding.

Do not use Eukroma®-Plus Cream in patients under the age of 12.

Q: What Eukroma®-Plus Cream is used for?

A: Eukroma®-Plus Cream is used to treat melasma also known as hyperpigmentation of the skin.

Q: Is Eukroma®-Plus Cream safe?

A: Eukroma®-Plus Cream is considerably safe as long as a patient uses it for prescribed condition and at prescribed doses.

Q: Can Eukroma®-Plus Cream be used in pregnant women?

A: Eukroma®-Plus Cream is strictly prohibited for women who are pregnant, planning to have a baby or breastfeeding.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 21-30 business days USD 15.00 per order
EMS  Trackable, where available 14-21 business days USD 25.00 per order

Delivery time is:

Registered Mail - 21-30 business days, price - USD 15.00, no signature is required on delivery.
EMS - 14-21 business days, price - USD 25.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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