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About Natrilix® SR

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Natrilix® SR is manufactured by Serdia Pharmaceuticals. Natrilix® SR prolonged-release tablets have the advantage of being taken less frequently as they release the Indapamide slowly over several hours, thus provide a steadier blood level of the medication throughout the day. The active substance comprised in Natrilix® SR is Indapamide, a sulfonamide (chlorosulphamoyl) thiazide-like diuretic and hypotensive agent.


- high blood pressure (hypertension);

- edema associated with congestive heart failure.

Natrilix® SR also can be used as an alternative oral agent for management of nephrogenic diabetes insipidus (do not confuse with diabetes mellitus or sugar diabetes), followed by abnormal production of urine (polyuria) and constant thirst (polydipsia). Natrilix® SR can reduce the urinary volume as well as increase its concentration without causing significant adverse effects.

MOA (mechanism of action):

Indapamide acts as a diuretic preventing kidneys from reabsorbing salt and excessive water. This results in the increased urine formation, so the unnecessary water leaves the body instead of being transmitted to the bloodstream. Indapamide is also thought to act as a muscle relaxant towards blood vessels walls due to its saluretic properties. When blood vessels got relaxed, the elevated blood pressure starts lowering. It also reduces left ventricular hypertrophy.


Natrilix® SR should be swallowed whole and taken with a glass of water.

Natrilix® SR releases the active ingredient Indapamide progressively over 24 hours.

Edema of congestive heart failure:

Start with taking 2,5 mg once daily in the morning. After 1 week of such schedule, the doctor will adjust the dose to the most suitable for you.

The average recommended dose varies up to 5 mg once daily.

Blood hypertension:

Start with taking 1,25 mg once daily in the morning. After 4 weeks of such schedule, the doctor will adjust the dose to the most suitable for you.

The average recommended dose varies from 2,5 to 5 mg once daily.


Do not exceed the dose of 5 mg a day.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is time for the next dose you should continue your regular dosing schedule. Do not take a double dose.


Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at a room temperature from 20 to 25 degrees C (68 to 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

Side effects

The most common side effects associated with the use of Natrilix® SR are:

  • red raised skin rash
  • allergic reactions (difficulty breathing, rash, itching, swelling on the face, lips, tongue)
  • nausea and vomiting
  • red pinpoints on the skin (purpura)
  • tiredness
  • headache
  • paraesthesia
  • vertigo
  • constipation
  • dry mouth

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.


Do not take Natrilix® SR if you are allergic to Indapamide or any other sulfonamide.

Do not take Natrilix® SR if you are allergic to any of the other ingredients comprised in Natrilix® SR.

Do not take Natrilix® SR if you have severe kidney disease, liver disease or hepatic encephalopathy (degenerative disease of the brain).

Do not take Natrilix® SR without medical supervision if you have thyroid disease, electrolyte imbalance, hypercalcemia, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, metabolic alkalosis, parathyroid disease, diabetes, gout, heart rhythm problems, and photosensitivity reactions.

Do not consume alcohol while taking Natrilix® SR as it may decrease an antidiuretic effect of the medication.

It is not recommended to combine Natrilix® SR with the use of antidepressants (lithium), heart rhythm medicines (quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, digitalis), anti-psychotics (clomipramine, imipramine, desipramine), angina pectoris treatments (bepridil), stomach medications (cisapride, diphemanil), antibiotics (sparfloxacin, moxifloxacin, erythromycin), memory loss treatments (vincamine), antiparasitics (halofantrine), pneumonia drugs (pentamidine), antihistamines (mizolastine), non-steroidal anti-inflammatory drugs (ibuprofen, acetylsalicylic acid), ACE inhibitors, anti-fungals (amphotericin), oral corticosteroids, stimulant laxatives, muscle medications (baclofen), potassium-sparing diuretics (amiloride, spironolactone, triamterene), calcium supplements, immunosuppresives (ciclosporin, tacrolimus), and hormones (tetracosactide).

Do not take Natrilix® SR if you need to have a test to check how well your parathyroid gland is working.

Do not use Natrilix® SR in patients under 18 years of age.

It is recommended not to use Natrilix® SR during pregnancy unless considered absolutely necessary by your doctor.

It is strictly prohibited to breastfeed during the Natrilix® SR treatment course.

Athletes should be aware that the use of Natrilix® SR may give a positive reaction in doping tests.

Q: What is Natrilix® SR used for?

A: Natrilix® SR is a mild oral diuretic used to treat high blood pressure (hypertension) and edema of congestive heart failure. This treatment lowers the blood tension without increasing the amount of urine much.

Q: Is Natrilix® SR safe?

A: Natrilix® SR is safe for adults and geriatric patients as long as used for prescribed condition and at prescribed doses.

Q: Can Natrilix® SR be used during pregnancy?

A: It is recommended not to use Natrilix® SR during pregnancy unless considered absolutely necessary by your doctor.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
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