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About Zytanix®

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Zytanix® is manufactured by Zydus Cadila Healthcare. The active substance comprised in Zytanix® is Metolazone, low ceiling quinazoline diuretic and sulfonamide derivative.


- edema associated with congestive heart failure, liver cirrhosis, renal diseases including the nephrotic syndrome, and states of diminished renal function.

- management of mild to moderate essential hypertension (alone or in combination with other antihypertensive drugs of a different class).

Zytanix® also can be used as an alternative oral agent for management of hypercalciuria, nephrolithiasis, and nephrogenic diabetes insipidus (NDI).

MOA (mechanism of action):

Metolazone belongs to carbonic anhydrase inhibitors and acts as an antihypertensive due to its potent saluretic and diuretic properties. It inhibits electrolytes and sodium reabsorption. By these actions, Metolazone makes the water existing in human blood leave the body as urine, instead of being reabsorbed into the bloodstream. With such excretion of unnecessary fluid, blood pressure starts lowering. Metolazone also has vasodilatory effect: it relaxes the muscles in the walls of blood vessels by retrieving the salt from them, thereby contributing to hypertension decrease as well.


Zytanix® tablets should be swallowed whole and taken with a few sips of water.

Blood hypertension:

The dosage, as well as the course duration, must be determined by a doctor for each individual patient.

The average recommended dose varies from 2,5 to 5 mg once daily.


The dosage, as well as the course duration, must be determined by a doctor for each individual patient.

The recommended starting dose varies from 5 to 10 mg once daily. If a loop diuretic is used concomitantly, the starting dose should not exceed 2,5 mg PO once daily.

If average recommended dose varies up to 20 mg daily.


The patients taking Zytanix® should be observed for clinical signs of fluid and/or electrolyte imbalance during the treatment course.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose.


If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.


Store at room temperature between 20 and 25 degrees C and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with the use of Zytanix® are:

  • abdominal pain
  • blurred vision
  • constipation
  • diarrhea
  • dry mouth
  • headache
  • allergic reactions (rash, hives, itching, raised welts, facial swelling, fever, difficulty breathing, peeling or blistering skin)
  • irregular heartbeat
  • chest pain

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.


Do not take Zytanix® if you are allergic to Metolazone or any other quinazoline diuretic.

Do not take Zytanix® if you are allergic to any of the other ingredients comprised in Zytanix®.

Do not combine Zytanix® with the use of antidiuretics.

Do not take Zytanix® if you have anuria, liver disease (hepatic coma or pre-coma), asthma, diabetes, gout, pancreatitis, hypercalcemia, hyperuricemia, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, systemic lupus erythematosus or kidney disease.

Do not consume alcohol while taking Zytanix® as it may decrease an antidiuretic effect of the medication.

Do not take Zytanix® if you are currently taking anti-inflammatory drugs for pain or swelling (aspirin, ibuprofen, naproxen, diclofenac), barbiturates for sleep or seizure control (secobarbital, pentobarbital, mephobarbital), heart medications (digoxin, dofetilide), antipsychotics (lithium), antidiabetics (chlorpropamide), high blood pressure medications (enalapril, perindopril, irbesartan), muscle relaxants (diazepam, lorazepam, clonazepam), urinary tract drugs (methenamine), other diuretics, steroid hormones (cortisone, hydrocortisone, and prednisone) or anticoagulants (warfarin).

It is recommended not to use Zytanix® in patients under 18 years of age.

It is recommended not to use Zytanix® in pregnant women unless considered absolutely necessary by your doctor.

It is strictly prohibited to breastfeed during the Zytanix® treatment course.

Q: What is Zytanix® used for?

A: Zytanix® is an oral diuretic for the treatment of edema associated with heart failure, renal diseases, and diminished renal function conditions. These tablets also have antihypertensive properties and are used to manage elevated blood pressure (hypertension).

Q: Is Zytanix® safe?

A: Zytanix® is safe for adults and elderly patients as long as used for prescribed conditions and at prescribed doses.

Q: Can Zytanix® be used in pregnant women?

A: It is recommended not to use Zytanix® in pregnant women unless considered absolutely necessary by your doctor.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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